The Outwood Academy City school in Sheffield confirmed it was closed following the "tragic incident" involving three of its students. "We don't know the details of the incident but it is imperative that families who come from Afghanistan are given all the support they need and housed in appropriate accommodation. The horror crash happened on the A57 Sheffield Parkway at around 1.24am today. 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"They are so upset, they are so unhappy," he said. The BBC is not responsible for the content of external sites. He had to drive home knowing he has lost his children. MND and FTD are devastating diseases which currently have no cure. Man arrested after four found dead in house, 'Ditzy and forgetful' comic Angela Barnes tours Hot Mess show to Derbyshire town, 'Copper's nose' leads officers to city home of dealer dad, Teenage thief used Facebook Marketplace to lure jewellery sellers from miles around, Derbyshire children transformed into fantasy characters for nine retro photos celebrating World Book Day, Buxton rail passengers thanked as railway reopens in Whaley Bridge, High Peak restaurant given new food hygiene rating, Angry protests erupt over Greek rail disaster, How fake copyright complaints are muzzling journalists, 1894 shipwreck confirms tale of treacherous lifeboat. FamilySearch. Copy Citation. Blades ready to 'fight and scrap' for promotion. A large cordon is in place and is being guarded by officers. South Yorkshire Police said: "Emergency services were called at around 3.45pm yesterday (Sunday, 25 April) following reports of concern for a woman in High Hazels Park, Sheffield. Office: 01-142-229-859, Copyright 2023 by the American Association for the Advancement of Science (AAAS), /Life sciences/Biochemistry/Biomolecules/, /Life sciences/Biochemistry/Biomolecules/Proteins/, /Life sciences/Biochemistry/Biomolecules/Proteins/Membrane proteins/, /Life sciences/Neuroscience/Cellular neuroscience/Neurons/, /Social sciences/Psychological science/Clinical psychology/Cognitive disorders/, Researchers from the University of Sheffields Institute of Translational Neuroscience have discovered how to prevent the death of nerve cells and protect nerves from neurodegeneration in the most common forms of MND and frontotemporal dementia, The researchers used a peptide, a small assembly of amino acids or protein bricks, with a cell-penetrating module to stop mutant repeated RNA molecules being transported from the cell's nucleus to the cytoplasm where they are used to produce toxic repeat proteins which lead to the death of nerve cells, Findings of the study suggest the peptide could be given orally in a non-invasive manner - for example through a nasal spray which could be developed to enter the brain, The groundbreaking concept of using peptides to block the nucleus-to-cytoplasm transport of the damaging repeat expanded RNA could transform how some neurodegenerative conditions, which currently have no cure, are treated. 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But it has. This study was made possible thanks to donated tissue samples from the skin of MND patients which were reprogrammed into nerve cells. A man has tragically died after his car came off the road in a horror crash in Sheffield's city centre. The woman was sadly pronounced dead at the scene. "I just want to kiss them and hold them. We understand Mohammed's father worked for the British Embassy in Afghanistan and had travelled to the UK under the government's scheme to resettle interpreters and support staff whose lives may be at risk from the Taliban. The new study, conducted by researchers at the University of Sheffields Institute of Translational Neuroscience (SITraN), also showed that using a peptide to stop the transport of mutant repeated RNA molecules and production of toxic repeat proteins actually increases the survival of C9ORF72 nerve cells - protecting them against neurodegeneration. 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"As a council we are in close contact with the police and will provide any support that we can to the family - my heart goes out to them.". There had been concerns raised about the safety of the windows. Hundreds of people from the Killamarsh community gathered at Baker Park near Chandos Crescent on Monday night for a vigil. Enquiries are ongoing. Scientists have found a novel way to block the transportation of mutant RNA and subsequent production of toxic repeat proteins which lead to the death of nerve cells in the most common subtypes of MND and FTD. The BBC is not responsible for the content of external sites. South Yorkshire Police have confirmed that emergency services were called to High A five-year-old Afghan refugee who fell to his death from a Sheffield hotel window has been identified by police. This concept of using peptides to block destructive mutations unlocks such an exciting and innovative treatment pathway which until now has not been explored by scientists. South Yorkshire Police have confirmed that emergency services were called to High Hazels Park in the Darnall area of Sheffield, yesterday afternoon. Attribution. Jin Wang took over KH Oriental from his own father who founded Sheffields largest Chinese supermarket on London Road in 1976. Sheff Wed. 4d. A man found unconscious in Sheffield city centre in the early hours of Saturday morning has tragically died in hospital. Ms Brierley died of serious head injuries, a post-mortem examination found. Read about our approach to external linking. I have three children and it was a very anxious time yesterday, not knowing what was happening. 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When I came here [outside] I saw the ambulance and police here. One of the mothers had tears in her eyes after lighting a candle. A man found unconscious in Sheffield city centre in the early hours of Saturday morning has tragically died in hospital. Welcome back Edit Account-Sign Out. The death is not being treated as suspicious.". This concept of using peptides to block destructive mutations unlocks such an exciting and innovative treatment pathway which until now has not been explored by scientists. MND is a debilitating condition that destroys the cells that control movement, leaving sufferers unable to move, walk, talk and eventually breathe. Or by navigating to the user icon in the top right. Search by name. Sign in. Det Ch Insp Andy Knowles said: "There's been a heightened police presence in and around Skelton Close today while we've completed enquiries at the scene to understand the circumstances surrounding this woman's death. Scientists have found a novel way to block the transportation of mutant RNA and subsequent production of toxic repeat proteins which lead to the death of nerve cells in the most common subtypes of motor neurone disease (MND) and frontotemporal dementia (FTD). 2023 BBC. FTD most commonly affects people aged 45-65 and can affect behaviour, personality, language and movement. The new study, conducted by researchers at the University of Sheffields Institute of Translational Neuroscience (SITraN), also showed that using a peptide to stop the transport of mutant repeated RNA molecules and production of toxic repeat proteins actually increases the survival of C9ORF72 nerve cells - protecting them against neurodegeneration. Two people have been charged with the murder of a woman found dead in a flat in Sheffield. As always you can unsubscribe at any time. Send your story ideas to yorkslincs.news@bbc.co.uk. Mrs Bennett said: "They were beautiful, well mannered kids. Police arrest man and woman for 'murder' as probe into death of Sarah Brierley at Sheffield home continues . He was later asked to accompany Mohammed's mother to hospital to translate. Sarah Brierley died from serious head injuries, police say, Police forced entry into the flat on Monday morning. "I met the father this morning and as you can imagine he's in a really bad way and all I could do is comfort him and pray with him, and he appreciated that.". The driver, a Sheffield man in his 30s, lost control over his car, which Read about our approach to external linking. "Some of you know the family, some of you know the children, some of you will have never seen them before. There is no cure for FTD, and no treatments available to slow or stop the progression of the disease. The BBC is not responsible for the content of external sites. Read about our approach to external linking. It is understood they were relocated to the UK as part of the Afghan Relocation and Assistance Policy (ARAP) scheme. Emergency services were called to the OYO Metropolitan Hotel in Blonk Street, Sheffield, at about 14:30 BST on Wednesday. "I continue to appeal that anyone with information about Sarah's death gets in touch.". We use your sign-up to provide content in the ways you've consented to and improve our understanding of you. Mary E. Fisher Hallam. Chief Constable Rachel Swann described the deaths as a "shocking event". The Universitys four flagship institutes bring together our key strengths to tackle global issues, turning interdisciplinary and translational research into real-world solutions. TikTok Queen and my beautiful boy, they were beautiful.". A man has tragically died after his car came off the road in a horror crash in Sheffield's city centre. Or by navigating to the user icon in the top right. His family have been informed and are being supported by specially trained officers at this time. Call 101, quoting incident number 853 of December 9 or Crimestoppers on 0800 555 111. It's understood the Home Office was directly managing the now empty hotel at the time of the incident. Video, 1894 shipwreck confirms tale of treacherous lifeboat, Latest news and stories from the East Midlands, Harry and Meghan told to 'vacate' Frogmore Cottage, Explosive found in check-in luggage at US airport, Fungus case forces Jack Daniels to halt construction, Rare Jurassic-era bug found at Arkansas Walmart, China and Belarus call for peace in Ukraine, Fire knocks out half of Argentina's power grid, Starbucks illegally fired workers over union - judge, Havana Syndrome unlikely to have hostile cause - US. a.l.pullan@sheffield.ac.uk Read about our approach to external linking. Search for obituaries & death notices in Sheffield Beyond. Most patients with the disease are only expected to live two to five years after diagnosis. Thug who ripped out clump of partner's hair in Leeds New Year's Eve assault 'only sorry he was caught', York to become the first place in the UK outside of London to run all-electric bus depot with the support of government funding, Hundreds criticise Sheffield's new Clean Air Zone over impact on small firms, 'It beggars belief': Judge condemns Sheffield man caught committing sex act while on train, Love Island final 2023: Maya Jama confirms date for the explosive final - how to watch, Constance Marten and Mark Gordon: Body found in search for missing baby, Angry protests erupt over Greek rail disaster, How fake copyright complaints are muzzling journalists, 1894 shipwreck confirms tale of treacherous lifeboat. Been concerns raised about the safety of the incident not being treated as.. Was sadly pronounced dead at the time of the windows there had been concerns raised the! 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